Catchment Scale Modelling of Water Quality and Quantity

Appropriately constructed pollutant export models can help set management priorities for catchments, identify critical pollutant source areas, and are important tools for developing and evaluating economically viable ways of minimising surface water pollution.¶ This thesis presents a comparison, an evaluation and an integration of models for predicting the export of environmental pollutants, in particular sediment, through river systems. A review of the capabilities and limitations of current water quality modelling approaches is made. Several water quality and quantity modelling approaches are applied and evaluated in the catchment of the upper Murrumbidgee River.¶ ..

Esports events: classification and impact of business model of video games on size

Esports events are not commonly researched in academic literature. This research aims to provide a higher degree of understanding around esports, esports events and their size, and to develop a framework for future research. Video game business models are considered, as their link with esports is not often examined. Overwatch is also investigated as a case study of a single video game and its associated esport. The methodology employed is based on mixed methods. A pragmatic approach is utilised, adjusting the research philosophy based on the most suitable approach for each part of the study. The research design evolves based on the findings and the methods used in the previous chapters. Chapter 4 utilises a mixed methods approach, chapters 5 and 6 both use a quantitative method, before chapter 7 uses a qualitative, case study like technique. Chapter 4 explores the determination of a framework to measure size of events and such framework is created, with 1 event being classed as ''giga'', 16 as ''mega'', 15 as ''major'', and 11 as ''minor''. Chapter 5 undertakes a similar pursuit but utilising an index to rank sizes. There are no large differences in score or in class, and there is a high degree of correlation between the index and the classification from the previous chapter. Chapter 6 explores event size vs. video game business model, finding that events associated to buy-to-play and free-to-play games have a larger size than events associated to pay-to-pay games. Chapter 7 analyses Overwatch and concludes that a switch to a free-to-play model would be beneficial for Overwatch, and for its associated esport Overwatch League. A number of recommendations are made as a result of the research undertaken. Better collection and organisation of data on esports would be beneficial for future research. A centralised governing body would help with a number of aspects in esports. More research could be undertaken into business models, into the implication of choosing one over another and switching between them. A research centre at the European level would also be beneficial, as would the growth of formal structures around esports and esports research

The Consequences of a Switch to Free-to-Play for Overwatch and Its Esports League

Videogames and their business models have evolved significantly over time, with consumers preferring a shift towards free-to-play (F2P) without any initial purchase, as evidenced in the popularity of Fortnite, Warzone and others. The aim of this research is to establish the viability of a switch from a buy-to-play (B2P) to a F2P model for the game Overwatch and the impact on its associated esports. The relevant literature within the subject area was identified. A framework was then developed to determine whether a switch to F2P would be successful for Overwatch, based on the criteria seen as significant within the literature identified. These criteria represent a mix of quantitative and qualitative approaches, and a mix of styles, with some being more descriptive with biographical elements of the author’s experience, and others being more analytical. The main conclusion drawn from the analysis undertaken is that Overwatch would be well suited for a switch to F2P. The sequel to Overwatch, Overwatch 2, is due to release in the near future, which would have opened the possibility of Overwatch being free, while Overwatch 2 is paid. However, Overwatch 1 is confirmed to be shutting down completely. It is also concluded there would be a likely increase in player numbers, and that a switch to F2P is likely to improve the problematic esports scene associated with Overwatch

Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology.

Between 6-20% of the cellular proteome is under circadian control and tunes mammalian cell function with daily environmental cycles. For cell viability, and to maintain volume within narrow limits, the daily variation in osmotic potential exerted by changes in the soluble proteome must be counterbalanced. The mechanisms and consequences of this osmotic compensation have not been investigated before. In cultured cells and in tissue we find that compensation involves electroneutral active transport of Na+, K+, and Cl- through differential activity of SLC12A family cotransporters. In cardiomyocytes ex vivo and in vivo, compensatory ion fluxes confer daily variation in electrical activity. Perturbation of soluble protein abundance has commensurate effects on ion composition and cellular function across the circadian cycle. Thus, circadian regulation of the proteome impacts ion homeostasis with substantial consequences for the physiology of electrically active cells such as cardiomyocytes

The evolving role of investigative toxicology in the pharmaceutical industry.

For decades, preclinical toxicology was essentially a descriptive discipline in which treatment-related effects were carefully reported and used as a basis to calculate safety margins for drug candidates. In recent years, however, technological advances have increasingly enabled researchers to gain insights into toxicity mechanisms, supporting greater understanding of species relevance and translatability to humans, prediction of safety events, mitigation of side effects and development of safety biomarkers. Consequently, investigative (or mechanistic) toxicology has been gaining momentum and is now a key capability in the pharmaceutical industry. Here, we provide an overview of the current status of the field using case studies and discuss the potential impact of ongoing technological developments, based on a survey of investigative toxicologists from 14 European-based medium-sized to large pharmaceutical companies